TY - JOUR
T1 - Bayesian Genomic-Enabled Prediction as an Inverse Problem
JF - G3: Genes|Genomes|Genetics
SP - 1991
LP - 2001
DO - 10.1534/g3.114.013094
VL - 4
IS - 10
AU - Cuevas, Jaime
AU - Pérez-Elizalde, Sergio
AU - Soberanis, Victor
AU - Pérez-Rodríguez, Paulino
AU - Gianola, Daniel
AU - Crossa, José
Y1 - 2014/10/01
UR - http://www.g3journal.org/content/4/10/1991.abstract
N2 - Genomic-enabled prediction in plant and animal breeding has become an active area of research. Many prediction models address the collinearity that arises when the number (p) of molecular markers (e.g. single-nucleotide polymorphisms) is larger than the sample size (n). Here we propose four Bayesian approaches to the problem based on commonly used data reduction methods. Specifically, we use a Gaussian linear model for an orthogonal transformation of both the observed data and the matrix of molecular markers. Because shrinkage of estimates is affected by the prior variance of transformed effects, we propose four structures of the prior variance as a way of potentially increasing the prediction accuracy of the models fitted. To evaluate our methods, maize and wheat data previously used with standard Bayesian regression models were employed for measuring prediction accuracy using the proposed models. Results indicate that, for the maize and wheat data sets, our Bayesian models yielded, on average, a prediction accuracy that is 3% greater than that of standard Bayesian regression models, with less computational effort.
ER -